A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones
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چکیده
منابع مشابه
Genetic analysis of polyketide synthase and peptide synthase genes of cyanobacteria as a mining tool for new pharmaceutical compounds
Cyanobacteria are considered a promising source for new pharmaceutical lead compounds and a large number of chemically diverse and bioactive metabolites have been obtained from cyanobacteria. Despite of several worldwide studies on prevalence of NRPSs and PKSs among the cyanobacteria, none of them included Iranian cyanobacteria of Kermanshah province. Therefore, the aim of this study was t...
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Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains a beta-ketoacyl synthase, an acyltransferase (AT), and an acyl carrier protein. Here we report that the leinamycin (LNM) biosynthetic gene cluster from Streptomyces atroolivaceus S-140 consists of two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of whic...
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Race T of the fungal pathogen Cochliobolus heterostrophus is highly virulent toward Texas male sterile (T) maize and differs from its relative, race O, at a locus (Tox1) that is responsible for the production of T-toxin, a family of linear long-chain (C35 to E41) polyketides. In a previous study, the restriction enzyme-mediated integration procedure was used to mutagenize and tag Tox1. Here, we...
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We identified a polyketide synthase (PKS) gene, pksN, from a strain of Nectria haematococca by complementing a mutant unable to synthesize a red perithecial pigment. pksN encodes a 2,106-amino-acid polypeptide with conserved motifs characteristic of type I PKS enzymatic domains: beta-ketoacyl synthase, acyltransferase, duplicated acyl carrier proteins, and thioesterase. The pksN product groups ...
متن کاملComprehensive Analysis of Polyketide Synthase Families
Polyketides (PKs) are a class of natural products (secondary metabolites) from bacteria, fungi, and plants, including many clinically important drugs such as tetracycline, daunorubicin, erythromycin, rapamycin and lovastatin [1, 4]. They have a large diversity of biological activities and pharmacological properties such as antibiotic, anticancer, antifungal, antiparasitic, cytostatic, and immun...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2018
ISSN: 0044-8249
DOI: 10.1002/ange.201805363